Papers: Paper #1:
Jinek, M., Chylinski, K., Fonfara, I., Hauer, M., Doudna, J. A., and Charpentier, E. “A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity.” Science (New York, NY) 337, no. 6096 (2012): 816–821. doi:10.1126/science.1225829,

Paper #2:
Shan, Q., Wang, Y., Li, J., Zhang, Y., Chen, K., Liang, Z., Zhang, K., Liu, J., Xi, J. J., Qiu, J.-L., and Gao, C. “Targeted Genome Modification of Crop Plants Using a CRISPR-Cas System.” Nat Biotechnol 31, no. 8 (2013): 686–688. doi:10.1038/nbt.2650,

Here is a general review:
Pennisi, E. “The CRISPR Craze” Science (New York, NY) (2013)

1. What are the possible applications of genome editing?
2. Would manipulating plants and other organisms by this technology be considered GMO?
Paper #1:
3. Can you think of another application for the D10A/H840A Cas9 nuclease?
Paper #2:
4. What are the advantages of homologous recombination in genome editing applications?